Voltammetric Determination of a Benzimidazole Anthelmintic Mixture at a Poly(3-methylthiophene)-modified Glassy Carbon Electrode

Abstract

The voltammetric determination of benzimidazole anthelmintics at a glassy carbon rotating-disk electrode modified with poly(3-methylthiophene) is presented. The purpose of surface modification was to improve the sensitivity and limits of detection for determination of the compounds in a standard mixture. Thus, five compounds, namely thiabendazole, mebendazole, albendazole, fenbendazole and oxibendazole have been studied using square wave voltammetry. It has been possible to resolve four of the compounds, mebendazole, fenbendazole, oxibendazole and thiabendazole, in a mixture. Investigations of a number of parameters, including the mode of potential application, cathodic reduction versus anodic oxidation, the type of electrode, effect of pH and speed of electrode rotation, among others, are reported.


South African Journal of Chemistry Vol.56 2003: 5-9