Article Sidebar
Published:
Feb 24, 2004Article Details
Issue
Section
Articles
Copyright for articles published in this journal is retained by the journal.
SAJChem applies the Creative Commons Attribution (CC BY) license to manuscripts we publish. This license was developed to facilitate open access – namely, free immediate access to, and unrestricted reuse of, original works of all types. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute or reuse these articles, as long as the author and original source are properly cited.
Main Article Content
Novel Synthesis of 1,6,7,9-Tetrasubstituted 8-Oxo-1-azaspiro[4.4]nonanes
Abstract
The synthesis and isolation of one diastereomer of 1-benzyl-7,9-dimethyl-8-oxo-1-azaspiro[4.4]nonane-6-carbonitrile 11 was accomplished by the diiron nonacarbonyl-assisted spirocyclization reaction of 2-(1-benzyl-2-pyrrolidinylidene)acetonitrile 10 and 2,4-dibromo-3-pentanone 12.NOESY NMR spectroscopy experiments of 11 showed it to be the (5R*, 6S*, 7S*, 9S*)-diastereomer.
South African Journal of Chemistry Vol.55 2002: 132-
South African Journal of Chemistry Vol.55 2002: 132-
