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The Synthesis of Substituted Piperazine-cholesterol Conjugates for use as Components of Nucleic Acid Transfection Lipoplexes
Abstract
A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.
Keywords: Piperazine, Cholesterol, Conjugates, Transfection, Cationic Lipoplexes
