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Published:
Oct 9, 2015Keywords:
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A Facile Catalyst-free Pudovik Reaction for the Synthesis of α-Amino Phosphonates
Abstract
Some imines were synthesized by the reaction of 5-amino 1-naphthol with substituted aromatic aldehydes in ethanol under reflux conditions. Dialkyl phosphites underwent addition with aromatic imines to give novel α-amino phosphonates. All the title compounds were characterized by elemental analysis, IR, 1H, 13C, 31P NMR and mass spectral data. All the newly-synthesized compounds (4a–j) exhibited moderate antibacterial and antifungal activity.
Keywords: 5-Amino-1-naphthol, imines, dialkyl phosphite, α-amino phosphonates, antimicrobial activity
