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Published:
Oct 9, 2015Keywords:
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1,5-Bis (2-Hydroxyphenyl)Pent-1,4-Diene-3-One: A Lead Compound for the Development of Broad-spectrum Antibacterial Agents
Abstract
A systematic and comparative study has been made starting from a naturally occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent 1,4-diene-3-one (1c) as a lead compound with potential against a panel of pathogenic bacterial strains, Staphylococcus (coagulase negative), Escherichia coli, Pseudomonas aeruginosa, Acenetobacter sp. and Klebsiella pneumoniae. Gentamycine and tetracycline were used as reference drugs. Themodeof antibacterial action of 1c was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. In vitro toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.
Keywords: Chalcone, Antibacterial Agent, MIC, α,β-unsaturated Carbonyl Compounds
