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KHSO4-catalyzed Three-component Synthesis of α-Aminonitriles
Abstract
Asimple, convenient and general method has been developed for the synthesis of-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO4 in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.
Keywords: One-pot, KHSO4, trimethyl silyl cyanide, α-aminonitriles
