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Highly Efficient Formylation of Alcohols, Thiols and Aniline Derivatives by a Heterogeneous (HCOOH/SiO2) System under Microwave Irradiation and Solvent-free Conditions
Abstract
A simple, rapid and efficient microwave-assisted procedure for the formylation of aniline derivatives and alcohols, using a heterogeneous (HCOOH/SiO2) system under solvent-free conditions is reported. The method is applied to a set of amines, alcohols and thiols and short reaction times (<10 min) with high yields are reported. This protocol introduces a practical and viable green technology of solvent-free and catalyst-free reactions.
Keywords: Alcohols, anilines, SiO2, HCOOH, microwave irradiation, solvent-free conditions