Article Sidebar
Keywords:
Article Details
Copyright for articles published in this journal is retained by the journal.
SAJChem applies the Creative Commons Attribution (CC BY) license to manuscripts we publish. This license was developed to facilitate open access – namely, free immediate access to, and unrestricted reuse of, original works of all types. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute or reuse these articles, as long as the author and original source are properly cited.
Main Article Content
Synthesis and Antimicrobial Activities of Some New Pyrazoles, Oxadiazoles and Isoxazole Bearing Benzofuran Moiety
Abstract
The synthesis of novel derivatives of pyrazole-3-carboxylate (3–5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1) is reported. Synthesis of substituted 1,3,4-oxadiazoles (7–11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting fromthe 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, 1H NMR, 13C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gramnegative bacteria and a fungus.
KEYWORDS 2,4-Dioxobutanoate, isoxazole, pyrazoles, pyrazole-3-carbohydrazide, 1,3,4-oxadiazoles.
