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An Expedient Method for the Synthesis of Acylhydrazones under Microwave Irradiation in Solvent-free Medium
Abstract
A simple, efficient and eco-friendly method for the synthesis of acylhydrazones from acylhydrazides and aldehydes under microwave (MW) irradiation was reported, no solvent and catalyst was used. The method is combined with a combinatorial approach and fourteen novel acylhydrazones were synthesized in excellent yields (89–96%) and short reaction times (less than 5 min).
KEYWORDS: Acylhydrazides, acylhydrazones, acylhydrazones, microwave, solvent-free.