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Published:
Sep 30, 2015Keywords:
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Synthesis of the Antimycobacterial Naphthoquinone, 7-Methyljuglone and its Dimer, Neodiospyrin
Abstract
We report on the laboratory-scale synthesis of the antimycobacterial naphthoquinone, 7-methyljuglone (7-methyl-5-hydroxy- 1,4-naphthoquinone) in a one step Friedel-Crafts acylation reaction. This compound was used to synthesize neodiospyrin, which possesses similar bioactivity.
KEYWORDS: 7-Methyljuglone; Friedel-Crafts acylation; neodiospyrin; antimycobacterial.
