Protein losing enteropathy in children - a Tunisian case series

Abstract

Protein-losing enteropathy (PLE) is a relatively rare entity with several causes and associations characterized by an excessive loss of protein from the gastrointestinal tract. The clinical presentation is variable and depends on the underlying cause. Given its rarity, under diagnosis may exist. The clinical presentation is ubiquitous due to the wide range of causes. The dominant clinical features is oedema, with or without pleural and pericardial effusions. Biochemically hypoalbuminemia, with invariable normal renal and liver function, is characteristic2,3. Diagnostic confirmation is based on the determination of fecal alpha-1 antitrypsin clearance. An appropriate evaluation for an aetiology is key to prompt management thereby limiting morbidity and even mortality