Hepatoprotective potentials of aqueous leaf and seed extracts of Artocarpus heterophyllus on testosterone propionate induced prostatitis in Wistar rats.

Abstract

This study evaluated the hepatoprotective potentials of aqueous leaf and seed extracts of Artocarpus heterophyllus on testosterone propionate induced prostatitis in Wistar Rat. Male Wistar rats of 100- 125g and 100 in number were obtained from the Department of Pharmacology, University of Port Harcourt animal house and was grouped into 10 of 10 rats each. The various groups were fed and administered with various concentrations (100mg/kg, 200mg/kg, 300mg/kg and 200mg/kg combined extract) of the leaves and seeds extracts of A. heterophyllus. The hepatoprotective potentials was studied by evaluating the liver function parameters on the male Wistar rats by day 21, 42 and 63 of the experiment using standard laboratory methods. The results obtained showed significantly (p< 0.05) increased ALP levels (401.57±0.85) on administration of testosterone propionate in group 2 (induced not treated group) day 21, as against the normal control group (294.57±0.06), while group 5 (Rats induced with TP (4 mg/kg) and administered 200 mg/kg of aqueous extract of A. heterophyllus leaves) revealed minimal level of ALP 293.47±0.006 by day 63. Minimum values for AST 23.00±0.51 was seen in group 8 day 21) with maximum activity 76.82±0.09 seen in group 1 day 21, ALT minimum level 7.67±0.33 was observed in group 4 day 21, while maximum levels 38.41±0.51 was seen in group 2 day 21, Albumin minimum level 17.87±0.09 was seen in group 2 day 63, with maximum level 31.13±0.18 observed in group 8 day 63, while minimum Total Protein 26.31±0.84 was shown in group 2 day 63 and maximum 64.63±0.49 in group 8 day 42. Obtained values from groups 5, 6, 9 and 10 were shown to be significantly different when compared with the negative control in group 2 but not significantly different with control group 1 and 3, hence depicting a more stabilized and hepatoprotective system in the plant extract treated groups compared to the negative control (group 2) at day 21. However, group 5 was shown to have higher hepatoprotective potentials by day 42 followed by group 10.