25-hydroxy vitamin D concentrations negatively correlated with HbA1c in type 2 diabetes mellitus patients: a cross-sectional study in Mampang, South Jakarta

Abstract

INTRODUCTION: Insulin resistance plays a central role in type 2 diabetes mellitus (T2DM). Another possible cause of T2DM is a deficiency o f 25-hydroxy vitamin D [ 25(OH)D], although the underlying mechanism is not yet clearly understood. The most frequently used laboratory parameters for monitoring T2DM are fasting blood glucose (FBG) and HbA1c. Determining any association of vitamin D with HbA1c and FBG in T2DM.

METHODS: A cross-sectional study involving 100 T2DM patients with the following characteristics: 18-year and older persons of both genders, not having kidney and liver disease, not on insulin therapy, not pregnant or lactating, a nd n ot consuming vitamin D i n t he last three months. Spearman’s correlation coefficient was use d to test any association of 25(OH)D with HbA1 c and fasting blood glucose (FBG) (p<0.05).

RESULTS: Subjects comprised 74 females and 26 males with a median age of 56 years. Median HbA1c, 25(OH)D, and FBG were 8.05%, 11.2 ng/mL, and 127 mg/dL, respectively. The Spearman correlation coefficient for vitamin D and HbA1c was r=-0.217 (p=0.03), and for vitamin D and FBG,
it was r =-0.153 (p=0.128).

CONCLUSION: There was a significant negative correlation of vitamin D with HbA1c but not with FBG. Administration of vitamin D should be considered for additional treatment of T2DM.