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Main Article Content
Emerging genetic profile of type 2 diabetes mellitus patients and controls in south western Nigeria: Catalyst for sustainable development
Abstract
Background: In sub-Saharan Africa, Type 2 diabetes care is greatly hampered by huge financial burden causing poor accessibility to healthcare. This study determined the genetic and environmental factors with potentials of attaining Goals 3 and 17 of the Sustainable Development Goals (SDGs) in Nigeria.
Methodology: This study was a case-control study. A multistage sampling technique was employed in the selection of 1500 patients with T2DM and 1500 controls in South Western Nigeria. Biophysical measurements and Glycaemic biomarkers were assessed for all respondents. Odds Ratio (OR) was determined with a level of significance was set at P<0.05
Results: The prevalence of Type 2 DM was 5%. However rural communities had older subjects with T2DM as compared with urban communities P<0.01. Glycaemic biomarkers and biophysical profiles were age and sex-related p<0.05 in both rural and urban communities. Transcription Factor 7 like 2 (TCF7L2) was found to be genetic marker of T2DM.
Conclusion: Transcription Factor 7 like 2 gene is a genetic marker of T2DM in Nigeria, which forms a framework for achieving goals 3 and 17 of the SDGs
