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Main Article Content
A retrospective assessment of rifampicin resistance in paediatric tuberculosis in a tertiary hospital in south west Nigeria
Abstract
Objectives: Children infected with tuberculosis, including drug resistant tuberculosis serve as reservoirs for Tuberculosis (TB) and as indicators of recent or ongoing transmission in the community. The aim of this study was to evaluate the prevalence of rifampicin resistance in paediatric tuberculosis in Babcock University Teaching Hospital, Ilishan Remo, Ogun State, Nigeria
Methodology: This was a retrospective study that involved a review of medical microbiology laboratory records to analyze GeneXpert results of sputum samples obtained from pediatric patients with tuberculosis between January 2017 and March 2022. Aconvenience sampling method was used to select cases who met the study's inclusion criteria until the sample size was attained.
Results: The medical laboratory records of 1046 subjects were analyzed in this study of which 556 (53.2%) were males. The mean age of all the patients was 10.77±4.38 years and majority of the respondents 445 (42.5%) were in the age group 11-15 years. Fifty patients (4.8%) had positive GeneXpert results of which 3 (6.0%) were Rifampicin resistant.
Conclusion: In order to lower the burden of TB globally more efforts should be made to reduce paediatric TB.
French title: Une évaluation rétrospective de la résistance à la rifampicine dans la tuberculose pédiatrique dans un hôpital tertiaire du sud-ouest du Nigéria
Objectif de l'étude: Les enfants infectés par la tuberculose, y compris la tuberculose pharmaco résistante, servent de réservoirs de tuberculose (TB) et d'indicateurs de transmission récente ou en cours dans la communauté. Le but de cette étude était d'évaluer la prévalence de la résistance à la rifampicine dans la tuberculose pédiatrique à l'hôpital universitaire Babcock, Ilishan Remo, État d'Ogun, Nigéria.
Méthode de l'étude : Il s'agissait d'une étude rétrospective qui impliquait un examen des dossiers de laboratoire de microbiologie médicale pour analyser les résultats GeneXpert d'échantillons d'expectorations obtenus auprès de patients pédiatriques atteints de tuberculose entre janvier 2017 et mars 2022. Une méthode d'échantillonnage de commodité a été utilisée pour sélectionner les cas répondant aux critères d'inclusion de l'étude. Critères jusqu'à ce que la taille de l'échantillon soit atteinte.
Résultat de l'étude : Les dossiers de laboratoire médical de 1 046 sujets ont été analysés dans cette étude, dont 556 (53,2 %) étaient des hommes. L'âge moyen de tous les patients était de 10,77 ± 4,38 ans et la majorité des répondants, 445 (42,5 %), appartenaient à la tranche d'âge de 11 à 15 ans. Cinquante patients (4,8 %) ont eu des résultats GeneXpert positifs, dont 3 (6,0 %) étaient résistants à la rifampicine.
Conclusion : Afin de réduire le fardeau de la tuberculose à l'échelle mondiale, des efforts supplémentaires doivent être déployés pour réduire la tuberculose pédiatrique.
