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Published:
Apr 7, 2020DOI:
10.4314/rejhs.v8i1.2Keywords:
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Main Article Content
Assessment of combined toxic effects of potassium bromateand sodium nitrite in some key renal markers in male Wistar rats
Abstract
Objective: Potential combined nephrotoxic effect following simultaneous administration of two food additives: potassium bromate (PBR) (20 mg/kg of body weight, twice weekly) and sodium nitrite (SNT) (60mg/kg of body weight as a single dose) orally was investigated.
Methods: Nephrotoxicity was assessed by determining urea, creatinine and electrolyte concentrations in the serum. In addition, concentrations of nitric oxide, reduced glutathione, total thiol, malondialdehyde and activities of arginase, adenosine deaminase, catalase, superoxide dismutase, and glutathione perioxidase in the kidney were investigated.
Results: The results revealed that individual exposure to PBR or SNT significantly induced nephrotoxicity and oxidative stress in rats however, this was enhanced by co-exposure as evidenced by significant alteration in these kidney markers when compared with the control.
Conclusion: This study accentuates the risk of enhanced nephrotoxicity in food containing both additives.
Key words: Potassium bromate, sodium nitrite, renal markers.
