The influence of hyperbaric oxygenation therapy on recurrent myocardial infarction and two-year survival rate in acute myocardial infaction patients

Abstract

<!-- /* Font Definitions */ @font-face {font-family:Garamond; panose-1:2 2 4 4 3 3 1 1 8 3; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:647 0 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0pt; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} -->

Background: Surgical methods of acute myocardial infarction (MI) treatment possess a high clinical effectiveness, but there are limitations, related to the patient's state, medical resources and organizational problems. The development of new medical technologies allows for a better and effective non-surgical treatment and increases long-term prognosis.

Aim: To assess the influence of hyperbaric oxygenation (HBO) therapy on mortality rate and recurrent myocardial infarction (rMI) within a two-year monitoring.

Methods: The study involved 129 patients who suffered from acute MI, having undergone the standard therapy. The patients were divided at random into 2 groups: Group 1 (reference group, n=65); Group 2 (test group, n=64). Group 2 patients were given the traditional treatment, accompanied with (HBO) standard therapy by BLKS-307 (Russia, Moscow) single-seat apparatus (isopression for 40 minutes at a working pressure of 0.03 MPa). HBO therapy was applied on the 4th- 10th day following MI. The treatment course included 6 cycles, once per day. The clinical assessment was focused on clinical outcome: repeated MI and cardiovascular related mortality. Monitoring duration was two years.

Results: The study involved 129 MI patients. No complications were encountered with HBO therapy on post-MI patients. Use of HBO reduced rMI and increased survival especially in the first half year after MI.

Conclusion: HBO application that accompanied the acute MI traditional pharmacotherapy proved to reduce rMI within 2 years following inpatient discharge (the rate of rMI was 19% in the reference group and 5.3% in the test group, χ2=5.0, р<0.05). The joint application of HBO and modern drug regimen in treating acute MI makes it possible to raise the 2-year survival rate from 86.2% up to 94.7%.

Key words: Hyperbaric oxygenation, Myocardial infarction, Mortality rate