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Published:
Dec 5, 2023Keywords:
Type 2 diabetes mellitus insulin kinetics field studies
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Implementation of longitudinal insulin kinetic studies in busy field settings in Uganda: experience from the "glucose metabolism changes in Ugandan HIV patients on dolutegravir based anti-retroviral therapy" (GLUMED study)
Abstract
Following the adoption of restrictive guidelines on the use of dolutegravir (DTG) in Ugandan persons living with HIV (PLHIV) known to have type 2 diabetes mellitus (T2DM) and those perceived to be at high risk of developing T2DM, we sought to describe longitudinal changes in insulin kinetics (insulin secretion, insulin resistance and insulin clearance) in a cohort of Ugandan PLHIV over 48 weeks. We adopted the oral glucose tolerance test method to carry out these studies, a method commonly used in tailored research institution laboratory settings. In this letter, we describe our experience performing these studies in a very busy, space limited public HIV clinic setting in a resource limited setting.
