Yannick Mayamba Nlandu
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo; Nephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo
Theodore-Junior Manyka Sakaji
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Yannick Mompango Engole
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo; Nephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo
Pitchouna Marie-France Ingole Mboliasa
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo; Nephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo
Dauphin Mulumba Bena
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Jessy Mukamamvula Abatha
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Jean-Robert Mpoke Nkumu
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Aliocha Natuhoyila Nkodila
Faculty of Public Health, Lomo University of Research, Kinshasa, Democratic Republic of the Congo
Karel Van Eckout
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Golan Kalifa
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Rodolphe Ahmed
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo
Justine Busanga Bukabau
Intensive Care Unit, Kinshasa Medical Center, Kinshasa, Democratic Republic of the Congo; Nephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo
Abstract
Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria status is a post hoc analysis of data from 80 COVID-19 patients admitted at Kinshasa Medical Center (KMC) from March 10th to July 10th, 2020. The population under study came from all adult inpatients (≥18 years old) with a laboratory diagnosis by polymerase chain reaction (PCR) of COVID-19 were selected and divided into two groups (positive proteinuria and negative proteinuria group). Logistic regression models helped to identify the factors associated with proteinuria. The P value significance level was 0.05. Among 80 patients who tested positive for SARS-CoV-2 RT-PCR, 55% had proteinuria. The mean age was 55.2 ± 12.8 years. Fourty-seven patients (58.8%) had history of hypertension and 26 patients (32.5%) diabetes. Multivariable analysis showed age ≥65 years (aOR 5,04; 95% CI: 1.51-16.78), diabetes (aOR 3,15 ;95% CI :1.14-8.72), ASAT >40 UI/L (aOR 7,08;95% CI:2.40-20.87), ferritin >300 (aOR 13,47 ;95% CI :1.56-26.25) as factors independently associated with proteinuria in COVID-19 patients. Proteinuria is common in Congolese COVID-19 patients and is associated with age, diabetes, ferritin and aspartate aminotransferase (ASAT).