Anis Mzabi
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Maissa Thabet
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Taghrid Tlili
Pathology Department, Farhat Hached Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Hend Zorgati
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Jihed Anoun
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Imen Ben Hassine
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Monia Karmeni
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Fatma Ben Fredj
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Moncef Mokni
Pathology Department, Farhat Hached Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Chadia Laouani
Internal Medicine Department, Sahloul Hospital, Faculty of Medicine Sousse, University of Sousse, 4000 Sousse, Tunisia
Abstract
Langerhans cell histiocytosis (LCH) is a rare systemic disease caused by proliferation of mature histiocytes; its association to histiocyto fibroma is rarely reported. It rarely affects adults. We report a case of systemic LCH, in an adult patient with osteolytic lesion causing a fistula between the left nasal cavity and hard palate, involving the bone, lung, lymph node and associated to multiple histiocyto fibroma. The patient was operating for a fistula, and he was treated by chemotherapy and corticosteroids. Langerhans´ cell histiocytosis is a rare case, especially in adult patient. The diagnosis was based on histological and immunohistochemical analyses. This patient was treated by steroids and chemotherapy.