Diagnostic value of saline infusion sonohysterography for detecting endometrium focal leson

Abstract

Introduction: different diagnostic tools are available to evaluate endometrial focal lesion such as hysteroscopy, sonohystrography and transvaginal
ultrasound. The present study aimed to determine the diagnostic value of saline infusion sonohystrography (SIS) in diagnosis of intrauterine lesions
in women with Abnormal Uterine Bleeding (AUB). Methods: this cross-sectional study recruited 100 married women with chief complain of AUB
referred to gynecologic clinics at the Amir Al-Momenin hospital, Semnan, Iran from March 2014 to February 2016. All participants were in the
reproductive age and post-menopausal period that showed abnormal endometrial thickness or endometrial focal lesions through transvaginal
ultrasound. Participants underwent SIS, hysteroscopy plus focal lesion resection and endometrial biopsy in order. The gold standard was the
histopathology of endometrial specimen reported by pathologist. Results: mean±SD age of women was 41.2±11.3 years. To diagnose the overall
focal lesions, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the SIS were 79.6, 89.1, 89.6, and 78.8%
respectively. These figures were 75.0, 87.5, 82.5 and 81.7%, respectively to diagnose polyps. The SIS sensitivity, specificity, PPV and NPV values to
diagnose the myomas were 60.0, 97.8, 75.0, and 95.7% respectively. Conclusion: findings show that, SIS probably is a proper method for detecting
endometrial focal lesion including polyps and myomas. Future studies may help to define further advantages of this procedure.