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Published:
Aug 16, 2021Keywords:
Anti-glomerular; basement membrane disease; nephrotic syndrome; proteinuria; case report
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Anti-glomerular basement membrane disease with intense nephrotic syndrome: a new case report
Ikram Mami
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Emna Ghzel
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Rym Abida
Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia; Department B of Internal Medicine, Charles Nicolle Hospital, Tunis, Tunisia
Fadwa Hlaoui
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Hela Jebali
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Lamia Rais
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Soumaya Beji
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Fethi Ben Hamida
Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia; Research Laboratory in Renal Pathology, Medicine School of Tunis, Tunis El Manar University, Tunis, Tunisia
Lilia Ben Fatma
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Karim Zouaghi
Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia
Abstract
Anti-glomerular basement membrane (anti-GBM)
disease was usually described as a small vessel
vasculitis presenting with acute kidney injury,
haematuria and non-nephrotic proteinuria. We
report a case of anti-GBM disease revealed by an
intense nephrotic syndrome. The urinary protein
level was 12g/day. Renal biopsy only showed
crescent glomerulonephritis with linear staining of
IgG in direct immunofluorescence without other
glomerulonephritis. Immunoglobulin G (IgG) antiGBM antibody titer was elevated.