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Transformation of a prostatic adenocarcinoma into squamous cell carcinoma after luteinizing hormone-releasing hormone agonist and radiotherapy treatment


Hamza Ichaoui
Sonia Ben Nasr
Faten Gargouri
Aref Zribi
Amine Hermi
Sana Fendri
Mehdi Balti
Jihen Ayari
Ramzi Khiari
Issam Msakni
Nada Mansouri
Samir Ghozzi
Abderrazek Haddaoui

Abstract

Squamous cell carcinoma of the prostate is rare and represents 0.5% to 1% of prostatic carcinomas. Transformation of prostatic adenocarcinoma into squamous cell carcinoma after LH-RH agonist intake has been reported in only 8 cases in the literature. To our knowledge, our case is the second pure squamous cell carcinoma observed after hormonotherapy and radiotherapy. We reported a case of a patient with prostatic adenocarcinoma treated by radical prostatectomy followed by radiotherapy. Eleven years later, he had a vesical recurrence of prostatic adenocarcinoma. Our patient had an endoscopic resection followed by injections of Triptorelin. Six months later, he developed a local recurrence of a squamous cell carcinoma.


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eISSN: 1937-8688