Corprological and haematological parameters of albino mice (Mus musculus) concurrently infected with Heligmosomoides bakeri and Trypanosoma brucei

Abstract

The effect of concurrent infection with Trypanosoma brucei (T. brucei) and Heligmosomoides bakeri (H. bakeri) was investigated in this study. Thirty adult male albino mice were used for the study. The mice were divided into six groups of five mice each. Group 1 served as uninfected control, Groups 2 and 3 were infected with H. bakeri and T. brucei respectively, Group 4 received both T. brucei and H. bakeri on the same day, Group 5 was experimentally infected with H. bakeri three days after T. brucei infection, while Group 6 was infected with T. brucei three days after H. bakeri infection. Blood and faecal samples were collected and analyzed weekly to determine the faecal egg counts (FEC), packed cell volume (PCV) and level of parasitaemia (LP). Weekly body weights (BW) were also recorded. FEC and parasitaemia increased in all the infected groups during the study, but these were significantly (p<0.05) higher in the multiple-infection (groups 4, 5 and 6) than those with the single infection (groups 2 and 3). The same trend was also observed in the BW and PCV (p<0.05). The level of infection produced by single infection with T. brucei and H. bakeri respectively were similar (p<0.05). All treatment groups were significantly (p<0.05) different from the control group. From the results, it was concluded that concurrent helminth and protozoan parasite infections produced more deleterious effect on the host when compared with single infection with either parasite. However, the pathology produced by concurrent infection was more severe when the host was exposed to the protozoan parasite before the helminth parasite.

Keywords: Albino mice, Concurrent infection, Heligmosomoides bakeri, Trypanosoma brucei.