Neonatal varicella following maternal chickenpox infection at term: a case report

Abstract

Maternal chickenpox resulting in neonatal infection is not common, considering widespread vaccination for chickenpox. Most women of child bearing age have antibodies against varicella zoster virus. However, when it does occur, the gestational age at onset markedly affects the severity of the illness in the fetus or newborn. The presence of maternal antibodies, use of passive immunization with zoster immune globulin and prompt institution of acyclovir once child shows evidence of illness has been shown to significantly reduce morbidity and mortality.

Keywords: Acyclovir, Zoster immunoglobulin, Varicella zoster virus, Passive immunity