In Vitro Anthelmintic Activity Of Anthocleista djalonensis

Abstract

The In Vitro anthelmintic activity of Anthocleista djalonensis a folkloric medicinal plant was studied using the L3 larvae of Heligmosomoides polygyrus. The ethanolic extract of A. djalonensis (25, 50, 100, 200 mg/ml) exhibited a concentration-dependent lethal action on H. polygyrus larvae. After 6 h incubation the percentage mortality at 100 mg/ml was 98.45%, which was equivalent to that of levamisole (the positive control) at 10 mg/ml. At 25 and 50 mg/ml, the percentage mortality was 89.36%. After 24 h incubation the percentage mortality of A. djalonensis extract was 41% at the highest concentration of 200 mg/ml, while levamisole at 10 mg/ml had 91%. Its LC50 was 268.89+56.26 mg/ml using Minitab probit analysis. In conclusion, the ethanolic extract of A. djalonensis exhibited a concentration-dependent lethal action on H. polygyrus.

Keywords: Anthocleista djalonensis, Heligmosomoides polygyrus, Extract, Levamisole

Nigerian Veterinary Journal Vol. 28 (1) 2007 pp. 9-13