The use of Time Urinary Collection and Prediction Equations in the Estimation of Creatinine Clearance in both Health and Disease

Abstract

Measurement of creatinine clearance was carried out on twenty subjects; ten male and ten female hypertensive and normotensive. Eight-hour and 24-hour timed urinary collections were used to calculate creatinine clearance in these subjects. These were compared with clearances calculated with the prediction equations developed by Cockcroft and Gault and also Taylor et al. There was statistically significant correlated between the 8 hours and the 24 hour values of creatinine clearance, but no correlation with clearance values calculated with prediction equations. The study recommends that in this environment, where it is not possible to supervise urine collection for 24 hours, the 8 hour urine collection which can be carried out within office hours and which correlated significantly with the 24 hour urine collection be used. The study also recommends that physicians be careful in the use of predicted creatinine clearance in renal disease until such a time that prediction equations are developed for the different renal disorders which exist.

NQJHM Vol. 14 (3&4) 2004: pp. 299-301