Modulatory Effects of Ascorbic Acid on Spermatoxicity of Artesunate in Rats

Abstract

This study examined the effects of short-term use of oral artesunate on testicular function in rats. Artesunate is an atermisinin derivative, now widely used to treat malaria. We also studied the modulatory effects of ascorbic acid (vitamin C) on any toxicity that might occur. We compared sperm parameters, serum testosterone, and the histology of the testis in 3 groups of Sprague Dawley rats treated with these agents for 7 days. Our results show that total sperm counts; motility and serum testosterone were significantly lower (P<0.05) in the artesunate treated animals than control. However ascorbic acid blocked and, more than compensated for this toxicity in the group that received artesunate and ascorbic acid concomitantly. This study showed that even short-term use of artesunate may impair spermatogenesis in rats. It also shows that modulating agents may prevent this effect. Its use in human males may require protective agents therefore.

Keywords: Sperm parameters, artesunate, serum testosterone and Ascorbic acid.

Nigerian Medical Practitioner Vol. 53 (4) 2008: pp. 62-65