Levels of Albuminuria and Serum Uric Acid and their Relationship in Hypertensive Patients in Southern Part of Nigeria

Abstract

Summary:

Worldwide, hypertension is the main modifiable risk factor for cardiovascular disease and premature death. It is also the main cause of morbidity and mortality in Nigeria. Several studies have reported a direct relationship between both microalbuminuria and elevated serum uric acid level and cardiovascular disease among patients with hypertension. This study was to assess the levels of albuminuria and serum uric acid and their relationship in patients with hypertension. This was a cross-sectional study conducted among three hundred participants including two hundred hypertensive and one hundred normotensive individuals, in Central Hospital, Warri, Delta State, between October 2022 and January 2023. The mean UACR was significantly higher in the hypertensives than in the controls (1.02 ± 1.42 vs. 0.28 ± 0.16 mg/mmol respectively, p < 0.001). The mean serum uric acid was significantly higher in the hypertensives than in the controls (0.26 ± 0.18 vs. 0.14 ± 0.03 mmol/l respectively, p<0.001). There was a significant weak positive correlation between UACR and SUA in the hypertensive group (Pearson's Correlation = 0.156, P-value = 0.027). The levels of UACR and serum uric acid were significantly higher in the hypertensives than in the controls. There was a weak positive correlation between UACR and serum uric acid in the hypertensive group.