Serum lipoprotein @ and cardiovascular risk factors among ambulatory healthy black subjects in Lagos, Nigeria

Abstract

This is a retrospective descriptive study to evaluate serum lipoprotein @ and cardiovascular risk factors among ambulatory healthy black subjects in Lagos, Nigeria. A total of 841 subject data were considered for this study spanning from 2014 to 2018. Lipoprotein @, HbA1c, fasting glucose were assayed using Cobas 6000 chemistry analyser under standard controlled conditions. Subjects' biodatas were retrieved from the laboratory information system of the healthcare facility. These data were entered into excel sheet and later exported to SPSS software package for windows version 25 for statistical analysis. Mean serum lipoprotein @ for this study (6.1mg/dl) was generally lower than that derived from earlier studies like the Copenhagen general population study. There was even male and female gender distribution of lipoprotein @. No statistical relationship between serum lipoprotein @ and observed CVS risk factors was derived in this study. This may be an indication of earlier findings that lipoprotein @ serum level is genetically determined. Serum lipoprotein @ is generally low among low-risk subjects used for this study and no relationship was derived when compared to CVS risk factors including age, hypertension, smoking, BMI and poor glycaemic control. Therefore, lipoprotein @ should not be considered as a first-line testing in the initial assessment of subjects when lipid profile testing is required. A robust control and genetic study will help delineate the usefulness of lipoprotein @ testing in the prediction of cardiovascular fatalities in humans.