In-vitro Experiment-based Selection of Effective Antibiotics for Use in Staphylococcus Epidermidis Infections in our Community.

Abstract

To identify local commonly-available antibiotics that can be used for the management of infections
caused by Staphylococcus epidermidis. A large number of clinical and community isolates of Staphylococcus.
Epidermidis was evaluated for antibiotic sensitivity using NCCLS (1997) technique. Minimum inhibitory
concentration was determined using macrotube double dilution protocol with and without 10% human serum.
All the isolates were then evaluated for â-lactamase producing status using iodometric procedure. Results
showed no significant difference in resistance (p>0.01) between the clinical and community isolates. MIC values
easily correlated with the antibiotic sensitivity profiles. â-lactamase production could not adequately account for
the resistance of the organism to â-lactam antibiotics. Ciprofloxacin and Gentamicin were clearly the most active
against all isolates and could be considered drugs of choice for treating infections caused by this organism.

Key Words: Selection, Effective Antibiotics, Staphylococcus, epidermidis, infections.