Comparative study of the severity of Covid-19 infection between female and male patients

Abstract

Background: Different studies have identified the prognostic factors of COVID-19 infection. These studies have revealed that COVID-19 infection is more severe in males than in females. Our study aimed to compare the severity of COVID-19 infection between males and females in terms of clinical, biological, radiological, and evolutionary aspects.
Methodology: This is a cross-sectional observational study conducted in patients hospitalized with COVID-19 infection over a 6-month period from 1 August 2021 to 1 February 2022.
Results: The comparison of clinical, biological, radiological, and evolutionary severity factors of covid19 infection between the two sexes revealed that this infection was more severe in males. Statistically significant differences were noted for the rate of high dimers (p =0.01) and for lung involvement greater than 25% on chest CT (Computed tomography) (p =0.008).
Conclusion: The severity of COVID-19 infection in men is due to biological differences between men and women in the renin-angiotensin system, the immune system, genetics, and sex hormones. Further research into the pathophysiological mechanisms behind this finding is needed.