Doxazocin in the management of benign prostatic obstruction in elderly Nigeria

Abstract

In a prospective study 14 patients with lower urinary symptoms from Benign Prostatic Hyperplasia (BPH) were given titrated doses of Cardura (Doxazocin) over a period of 4 weeks. The response to the drug was measured weekly using the International Prostate symptom scores, (IPSS) Quality of life score, urine flow rate, and post-void residual urine volume. All (100%) the patients recorded decreases (improvements) in the IPSS, and quality of life scores. Similarly all the patients recorded increases in urine flow rate, 9 (64.3%) of these reached to a level that enabled the operative treatment of their condition to be deferred. Ten(71.4%) of the patients had decreases in their blood pressures which was more profound in the hypertensive patients. The drug was well tolerated.

Nigerian Journal of Surgical Sciences Vol.16(1) 2006: 16-21