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Antiulcer and gastric antisecretory effects of landolphia owariensis extracts in rats
Abstract
and 200mg/kg) orally once daily for two weeks significantly reduced formation of ulcers induced by HCl/ethanol mixture, the percentage inhibition being 43.8% and 55.27% respectively. The Chloroform extract afforded the least protection with 23.07% and 14.77% inhibition. This was also accompanied by significant increases in gastric mucus production. In pylorus ligated rats, total volume of gastric juice and gastric acidity was significantly decreased as
compared to control group, to levels comparable to that produced by cimetidine. The results indicate that the leaf extracts of LO contains antiulcer principles.