Anti-lipid peroxidative activity of Gongronema latifoluim in streptozotocin-induced diadetic rat

Abstract

Summary: This study was designed to investigate the anti-lipid peroxidative effects of aqueous extracts from Gongronema latifolium (Utazi) leaves in non-diabetic and streptozotocin-induced diabetic rats. We evaluated plasma lipid peroxidation product (malondialdehyde, MDA) and antioxidant enzyme, superoxide dismutase (SOD) in all the animals. Result demonstrated that the untreated diabetic rats were subjected to oxidative stress as indicated by significantly (P<0.05) low level of their antioxidant enzyme, superoxide dismutase (49. 86 ± 2.04 U/mg protein) and high plasma lipid peroxidation index (6.82 ± 2.04 nmol/ml) when compared with non-diabetic rats value of 82.5 ± 3.16 U/mg protein and 2.66 ± 0.72 nmol/ml respectively. The aqueous extract of G. latifolium leaves reversed this situation as shown by significantly (P<0.05) increase in the activity of superoxide dismutase (78.6 ± 3.26 U/mg protein) and decreased levels of plasma malondialdehyde (4.02 ± 0.64). In conclusion, the results suggest that aqueous extract of G. latifolium leaves possesses hypoglycemic as well as anti-lipid peroxidative properties.

Key Words: Diabetes, lipid peroxidation, G. latifolium.