Piroxicam-Loaded P90gylated Tallow Fat-Based Solid Lipid Microparticles: Characterization and in Vivo Evaluation

Abstract

The purpose of this study was to develop solid lipid microparticles (SLMs) loaded with piroxicam, intended to be orally administered, able to improve the solubility of the drug yet devoid of adverse effects of piroxicam especially upon chronic use. Piroxicam-loaded P90Gylated tallow fat SLMs were prepared by the hot homogenization method. Here we report SLMs prepared from a combination of P90G and homolipid from Bos indicus (tallow fat) and evaluated for intestinal delivery of piroxicam. The investigated properties of the SLMs included particle size and morphology, thermal properties, drug loading efficiency, storage stability studies and injectability. The result dose-dependently showed high encapsulation efficiency up to 57 % and 92.49 % protection (inhibition) against electrical heat-induced pain (antinociception) where as 96.33 % inhibition of pedal oedema (anti-inflammatory activity) was recorded in the animal models.

Keywords: Piroxicam ; P90Gylated solid lipid microparticles ; tallow fat, anti-inflammatory activity

Nigerian Journal of Pharmaceutical Research, Vol. 8 No 1 pp. 19 - 35 (September 2010)