The use of liquid self-emulsifying drug delivery systems based on peanut oil/tween 80 in the delivery of griseofulvin

Abstract

Peanut oil and Tween 80 were employed in the formulation of liquid self-emulsifying drug delivery systems (LSEDDS) containing griseofulvin. The LSEDDS were evaluated using the following parameters: phase separation, globule size, viscosity, solubility of griseofulvin and partition coefficient. The release profile of griseofulvin from the optimized
LSEDDS was evaluated in acetate buffer solutions of different pH (pH 6.5, 7.4 and 2.0). Results obtained indicated that there was significantly higher (P=0.05) percentage cumulative amounts of griseofulvin released from the LSEDDS in comparison with that released from peanut oil alone. The release of griseofulvin from the LSEDDS into aqueous media of pH 6.5 and pH 7.4 showed enhanced dissolution of the drug from the formulation