A comparative evaluation of pentazocine and dipyrone on diazepam-induced sleep in mice

Abstract

This work reports on the evaluation of pentazocine and dipyrone analgesics on diazepam-induced sleep in mice. Diazepam (10 mg/kg) administered intraperitoneally (ip) was used to determine the onset and duration of sleep in mice and the mean of both set values were calculated and recorded. Pentazocine 20, 30 and 50 mg/kg administered (ip) was found to significantly decrease the onset of diazepam (10 mg/kg) induced sleep dose dependently (P<0.001)
while lower doses of 5, 10 and 15 mg/kg had no significant effect on the onset of sleep. Doses ranging from 15-50 mg/kg were found to significantly increase the duration of sleep dose dependently (P<0.001). However, 5 and 10 mg/kg produced no significant effect on duration of sleep. On the other hand, dipyrone (5-50 mg/kg) significantly increased the onset of diazepam-induced sleep (P<0.002, P<0.001). A15-50 mg/kg of dipyrone significantly decreased duration of sleep with increase in dose (P<0.001). Lower doses (5 and 10 mg/kg) of this drug did not produce any significant effect on sleep duration in mice. It is concluded that pentazocine potentiates diazepaminduced sleep while dipyrone antagonizes diazepam-induced sleep in mice dose dependently by decreasing its duration.© 2006: NAPA. All rights reserved.