Evaluation of the anti-ulcer activity of aqueous stem-bark extract of Hymenocardia acida (family – Euphorbiaceae)

Abstract

To assess and establish the scientific basis for the anti-ulcer activity of aqueous stem-bark extract of Hymenocardia acida. Groups of albino rats were pre-treated orally with aqueous stem-bark extract of the plant before administration of indomethacin and induction of cold-restraint stress ulcers by immobilizing each animal in a cylindrical cage maintained at 2 to 4^oC in a refrigerator for 3 hours. The animals were sacrificed by a blow on the head, their stomachs removed and examined for ulcers. The extract produced significant (P< 0.05) anti-ulcer activity against the two models studied. The anti-ulcer activity against cold-restraint stress was also dose-dependent. Phytochemical studies revealed the presence of glycosides, saponins and tannins. This study demonstrates that the plant extract has significant anti-ulcer activity against experimentally induced gastric lesions.

Key words: Antiulcer activity: Hymenocardia acida; Rats

Nig. J. Pharm. Res. 3(1) 2004: 86-90