The suspending properties of Cissus rubiginosa fruit mucilage in paracetamol suspension formulation

Abstract

Background: Materials with suspending properties like mucilage have been obtained from natural sources and used to stabilize liquid formulations containing poorly dispersible solids.

Objective: The aim of this study was to evaluate the suspending properties of Cissus rubiginosa fruit mucilage (CRM) in paracetamol oral suspension.

Materials and Methods: Paracetamol suspensions containing 0.5, 1.0, 1.5 and 2.0 %w/v CRM were prepared and compared with suspensions formulated with same concentrations of compound tragacanth (CT). The sedimentation volume, ease of re-dispersibility, effect of shear rate on viscosity, flow rate and drug release pattern were studied as assessment parameters.

Results: Characterization studies of the suspensions revealed that there was a corresponding increase in the viscosity of the suspension with increase in the concentration of the gum. Paracetamol suspension having CRM had significantly higher viscosity (p<0.05) compared to those containing CT. The viscosities of all suspensions decreased with increase in shear rate. There was decrease in flow rate as the viscosity of the suspension increased. Paracetamol suspensions containing CRM were easily re-dispersible with minimum agitation at concentration less than 1.0 %. Drug release from the suspension containing 0.5 % CRM was rapid while release from suspension containing higher concentrations of CRM occurred at a later time, eliciting a delay in drug release.

Conclusion: This study has been able to elucidate the ability of Cissus rubiginosa fruit mucilage to act as a suspending agent in pharmaceutical suspensions.

Keywords: Cissus rubiginosa mucilage, compound tragacanth powder, Suspension, Suspending agents