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Anti-plasmodial activity of ethanolic stem bark extract of Piliostigma thonningii Schum (Caesalpiniacea) in mice infected with Plasmodium berghei berghei
Abstract
Piliostigma thonningii Schum (Caesalpiniacea) is used traditionally in the management of fever, cough, wounds and various ulceration. Oral acute toxicity of the ethanolic stem bark extract of Piliostigma thonningii was evaluated in mice using modified Lorke.s method. The ethanolic stem bark extract was evaluated for in vivo anti plasmodial activity against chloroquine
sensitive strain of Plasmodium berghei berghei NK65 in mice. Four day suppressive test, curative effect against established infection and prophylactic models of anti plasmodial studies were carried out. The oral median lethal dose was determined to be = 5000mg/kg body weight. The extract (100, 200 and 400 mg/kg) exerted dose dependent chemo suppressive effects at the
different levels of the infections tested. However the anti-plasmodial effect of chloroquine at 5mg/kg body weight was higher than the extract in all the test models. This shows that the plant has anti plasmodial property that can be explored for the management of malaria.
sensitive strain of Plasmodium berghei berghei NK65 in mice. Four day suppressive test, curative effect against established infection and prophylactic models of anti plasmodial studies were carried out. The oral median lethal dose was determined to be = 5000mg/kg body weight. The extract (100, 200 and 400 mg/kg) exerted dose dependent chemo suppressive effects at the
different levels of the infections tested. However the anti-plasmodial effect of chloroquine at 5mg/kg body weight was higher than the extract in all the test models. This shows that the plant has anti plasmodial property that can be explored for the management of malaria.
