Comparative Study on the Efficacy of three Commonly Used Antibiotics (Nalidixic Acid, Ciprofloxacin and Ofloxacin) against Urinary Coliform

Abstract

The antibacterial in vitro-activity of Nalidixic acid, Ciprofloxacin and Ofloxacin were studied against 100 strains of urinary isolates between June 2012 and July 2013. Of the total number of  100 urine samples screened from different respondents, 60 isolates were positive for coliform organisms, 24 tested for non-coliform organisms while 16(16%) yielded no bacterial growth. Urinary coliforms isolated were highly susceptible to ciprofloxacine 30(50%) followed by ofloxacin 26(43.3%) and had a high resistance to chloramphenicol 56(43.3%) respectively. Non-coliform organisms also  exhibited  the  same  pattern  of  resistance  as  coliform  organisms  but  showed  high  resistance  to  both chloramphenicol and streptomycin with  22(91.7%) respectively. Escherichia coli showed  highest incidence occurrence of (50%) while citrobacter.spp recorded least with (10%). Females were more infected than the male respondents and infection most common in age bracket 20-23years. The treatment success was neither dependent on age nor sex. Therefore, it was concluded that ciprofloxacine is the best first line antibiotic, effective for urinary tract infection (U.T.I) in this region.

Keywords: Urinary tract infection, Coliform and antibiotics.