Immunomodulatory Activity Of Saponin Mixture Isolated From Lagenaria Siceraria Fruits

Abstract

An attempt has been made to assess the immunomodulatory activity of purified saponin mixture (PSM) isolated from the fruits of Lagenaria siceraria at three dose levels ranging from 50-150 mg/kg body weight in mice using haemagglutination antibody (HA) titre, delayed type hypersensitivity (DTH) and carbon clearance parameters. PSM increased haemagglutination antibody titre and carbon clearance significantly but inhibited delayed type hypersensitivity response in a dose dependent manner. Thus, present study, for the first time, demonstrated the immunomodulatory activity of Lagenaria siceraria fruits.