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Hypoglycaemic Potential Of Bridelia Micrantha (Hochst) Baill
Abstract
The anti-diabetic activity of extracts and fractions from leaves of Bridelia micrantha was investigated in alloxan diabetic rats. Powdered leaves of B.
micrantha were macerated with 80% MeOH for five days. The petroleum ether, CHCl3 and MeOH/H20 soluble portions were prepared from the crude aqueous MeOH extract and tested on the diabetic rats. Hyperglycaemia was induced by intraperitoneal injection of alloxan monohydrate (80mg/kg) and blood glucose monitored for seven days using a glucometer. The MeOH/H2O residue exhibited significant (p<0.05) reduction of blood glucose of 34.2% when compared to control rats. This result provides a rational scientific basis for the ethnomedicinal utilization of this plant.
micrantha were macerated with 80% MeOH for five days. The petroleum ether, CHCl3 and MeOH/H20 soluble portions were prepared from the crude aqueous MeOH extract and tested on the diabetic rats. Hyperglycaemia was induced by intraperitoneal injection of alloxan monohydrate (80mg/kg) and blood glucose monitored for seven days using a glucometer. The MeOH/H2O residue exhibited significant (p<0.05) reduction of blood glucose of 34.2% when compared to control rats. This result provides a rational scientific basis for the ethnomedicinal utilization of this plant.
