Evaluation Of Antimitotic And Anticancer Activity Of The Crude Extracts Of Pterospermum acerifolium Willd Leaves (Sterculiaceae)

Abstract

Pterospermum acerifolium is used traditionally in the management of tumors. Ethanol and Water extracts showed good antimitotic activity against
meristamatic cell growth. Both extracts also showed good inhibition on yeast cell growth with IC50 47.88 mg/ml and 39.15 mg/ml respectively. The mode of action of both extract with antiproliferative activity is due to fragmentation effect on DNA.

Keywords: Pterospermum acerifolium, Sterculiaceae, Antimitotic activity, Allium cepa model, antiproliferative activity, DNA fragmentation assay

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 76-79