Toxicological Evaluation And Antinociceptive Effects Of Wrightia tomentosa In Mice

Abstract

Acute toxicity testing and the antinociceptive activity in mice of ethanolic extract of Wrightia tomentosa leaves and bark were carried out. The bark extract (400mg/kg) exhibited maximum antinociceptive action after 120 minutes of administration with a value of 14.67 ± 4.17 seconds in comparison with standard aspirin having the reaction time of 8.33 ± 1.72 seconds after 120 minutes. The leaf extract was not as active.

Keywords:Wrightia tomentosa, Apocynaceae, Antinociceptive, Toxicity testing

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 64-66