Prostaglandin E2 (PgE2) Inhibition By Crude Extracts Of Selected Medicinal Plants From Botswana

Abstract

This study was undertaken to assess anti-inflammatory activity of crude extracts of Cassine transvaalensis Burtt-Davy, Clerodendrum uncinatum Schinz and Commiphora glandulosa Schinz using COX inhibition assay. Water extract of C. transvaalensis root bark (125mg/ml) exhibited a (90%) PGE2 inhibition in lipopolysaccharide (LPS) induced RAW 264.7 macrophages. This was a very good anti-inflammatory activity comparable to the control drug indomethacin (100%) at 0.4mg/ml. Chloroform extracts of C. uncinatum root (1.25mg/ml) and C. glandulosa stem resin (1.25mg/ml) exhibited good PGE2 inhibition (44% and 38%) respectively.

Keywords: Anti-inflammatory activity; PGE2 inhibition; LPS induced Raw 264.7 macrophages; Botswana plants.

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 32-33