Anti Coagulation And Antithrombotic Effects Of Triclisia Dictyophylla

Abstract

Triclisia Dictyophylla (moonseed) root was investigated for the anticoagulation and antithrombotic properties. The median lethal dose (LD50) based on
Lorke\'s methods was 550mg/kg. The aqueous root extract of T. dictyophylla prolonged the in-vitro whole human blood clotting time at concentrations of 50mg/2ml and 100mg/2ml of whole blood and at a concentration of 200mg/2ml of whole blood, complete anticoagulation effect was achieved. The prothrombin time of the different concentrations was unattainable even after 48hours. At a concentration of 200mg/2ml of semi clotted whole blood (invitro),
the clot was dislodged. The roots extract of T. dictyophylla has in-vitro anticoagulation and antithrombotic properties, perhaps justifying its use in the treatment of edematous pain.

Keywords: Triclisia Dictyophylla, Menispermaceae, human blood, coagulation, Fibrinolysis, antithrombosis

Nigerian Journal of Natural Products and Medicine Vol. 11 2007 pp. 29-31