Isolation and characterization of three cyclopeptides from the seeds of Annona glauca and A. cherimola

Abstract

This paper describes the isolation and structure elucidation of three cytotoxic cyclopeptides, named glaucacyclopeptide B (2), cherimolacyclopeptide G (1) and H (2), from the seeds of Annona glauca and A. cherimola. Techniques used in the structure determination included MS/MS fragmentation using a QTOF mass spectrometer equipped with an ESI source, chemical degradation and one- and two dimensional NMR and IR spectroscopy.

Keywords: annonaceae, seeds, cyclopeptides, glaucacyclopeptide B; cherimolacyclopeptide G, cherimolacyclopeptide H

Nigerian Journal of Natural Products and Medicine Vol. 9 2005: 68-72