Hepatoprotective activity of the fruits of Momordica dioica

Abstract

The flavonoidal fraction collected from column chromatography from ethanolic extract of fruits of Momordica dioica Roxb was evaluated for hepatoprotective activity in wistar strain of albino rats of either sex against carbon tetrachloride induced hepatic damage. The fraction caused decrease in serum level of enzymes serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphate and total bilirubin in treated rats as compared to control. This study showed that this fraction from Momordica dioica fruits could afford a good protection against carbon tetrachloride induced hepatocellular damage.

Keywords: hepatoprotective, Momordica dioica, cucurbitaceae, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphate, total bilirubin

Nigerian Journal of Natural Products and Medicine Vol. 9 2005: 29-31